Table 3.

Mutations in block Q versus S residual tumor foci in neoadjuvant abiraterone/leuprolide trial

Block S focusBlock Q focus
Tumor focusGeneTypeChangeFrequencyDepthFrequencyDepthNormal depthCOSMIC
QSABCA7MissenseD99N19.67%6115.56%4539
QSAMACRMissenseR171C18.75%3213.79%2929
QSARAFMissenseM545I12.82%7827.91%12984
QSCACNA1FFrameshift+1 bp codon 58815.00%4014.29%7751
QSCCDC14MissenseL804F15.22%4625.00%3262
QSCHEK2MissenseS110F42.11%3813.79%2983
QSDCHS1NonsenseQ769X18.87%5315.18%19151
QSDNAH11MissenseS508N14.29%2116.00%2570
QSGPR125MissenseA1181V14.29%4211.54%2637
QSPINK1NonsenseQ180X23.68%3816.51%10937
QSSLC5A2MissenseG488E24.24%3317.65%3428
QSTLN1MissenseA361V11.67%6014.29%2197Yes
SARMissenseT878A46.88%321737Yes
SMLH1Frameshift−1 bp codon 45637.11%97133125
SATMMissenseR2060H46.49%1144157Yes
SBAI3MissenseR725Q46.92%130125143
SBOCMissenseR3H45.31%6411041Yes
SCNGA2MissenseM378I46.81%475588
SEHMT1MissenseD964N49.19%124100151
SFN1MissenseT1211I46.83%126160195
SGALNTL1Frameshift−2 bp codon 53947.83%465964
SHDAC6MissenseR862K48.00%7515981
SIDH3BMissenseA282T47.13%8798168
SMFSD4MissenseS156N48.65%3714870Yes
SMYBPC1MissenseG483E46.07%895656Yes
SPRICKLE4Frameshift−1 bp codon 37445.57%7916584
SRMND5BMissenseT71K45.24%4213487
SRPS6KL1MissenseA270S48.84%43115119
STMEM27MissenseV81I48.65%373939
SUNKMissenseV761M46.75%16999272
SWDFY4MissenseP3109S48.68%768662
QADAMTS12MissenseP1139S3744.12%3448Yes
QAIFM1MissenseG138V5535.90%39140Yes
QCLCMissenseP34L2243.33%3040Yes
QGREB1LMissenseT1401I5539.13%4648
QLOXL1NonsenseQ44X6037.93%2961
QMLLT4MissenseV994M6237.04%2741
QNLNMissenseP181L3543.90%4143
QRPTNMissenseS416R10944.44%27130
QSASH1NonsenseQ1136X17547.12%278184
QSASH1MissenseD1140Y22241.64%305273

NOTE: Mutations in the COSMIC database as having been previously identified in cancer are indicated.