Table 4.

Inhibition of skin Gli1 mRNA (pharmacodynamic-evaluable population)

Dosing cohort (n)Mean inhibition of Gli1 mRNA relative to control genesa, % (SD)Mean inhibition of Gli1 mRNA relative to Smo, % (SD)
50 mg (1)94.2 (NA)94.5 (NA)
100 mg (4)92.7 (4.1)92.8 (5.1)
200 mg (4)92.6 (5.0)92.2 (5.6)
400 mg (4)94.5 (2.7)93.5 (3.5)
800 mg (4)92.8 (2.2)91.9 (2.4)
1,600 mg (4)87.3 (18.0)89.9 (13.6)
Total (21)92.1 (7.9)92.2 (6.4)

Abbreviations: Gli1, glioma-associated oncogene homolog 1; mRNA, messenger ribonucleic acid; SD, standard deviation, Smo, Smoothened.

  • aControl genes were B2M, POLR2A, and RPLP0.