Table 1.

Patient and tumor characteristics of the 1,090 patients in relation to daily coffee consumption (cups/day)

AllLow (0–1)Moderate (2–4)High (5+)
(n = 1,090)(n = 202)(n = 668)(n = 220)Ptrend
Patient characteristics, median (IQR)
 Age at diagnosis, y61.2 (52.1–68.1)59.4 (48.6–67.8)62.7 (55.0–69.3)58.6 (49.5–65.6)>0.3a
 Weight (kg)69.0 (62.0–78.0)68.0 (60.0–74.6)70.0 (62.0–79.0)69.2 (61.0–79.0)>0.3a
  Missing3681810
 Height (m)1.65 (1.62–1.70)1.65 (1.61–1.69)1.65 (1.62–1.70)1.67 (1.63–1.70)>0.3a
  Missing3681810
 BMI (kg/m2)25.1 (22.5–28.4)24.5 (21.9–27.7)25.2 (22.8–28.6)25.0 (22.6–27.9)>0.3a
  Missing3882010
 Waist-to-hip ratio0.86 (0.81–0.91)0.86 (0.81–0.90)0.86 (0.81–0.90)0.87 (0.82–0.91)>0.3a
  Missing53132317
 Total breast volume (mL)1,000 (650–1,500)925 (550–1,463)1,000 (700–1,600)950 (600–1,400)>0.3a
  Missing1783610141
 Age at first full-term pregnancy (y)25.0 (22.0–28.0)26.0 (23.0–29.0)24.0 (21.0–28.0)24.0 (21.0–28.0)0.009a
  Missing140338522
 Current smoker, n (%)219 (20.1%)18 (8.9%)119 (17.8%)82 (37.3%)<0.001b
  Missing4130
 Alcohol abstainer, n (%)116 (10.6%)33 (16.3%)70 (10.5%)13 (5.9%)0.001b
  Missing3021
Tumor characteristics, n (%)
 Invasive tumor size (pT)
  1785 (72.0%)134 (66.3%)485 (72.6%)166 (75.5%)0.013b
  2287 (26.3%)60 (29.7%)175 (26.2%)52 (23.6%)
  316 (1.5%)8 (4.0%)6 (0.9%)2 (0.9%)
  42 (0.2%)02 (0.3%)0
 Node status
  0668 (61.4%)116 (57.7%)419 (62.8%)133 (60.5%)>0.3b
  1–3326 (30.0%)65 (32.3%)192 (28.8%)69 (31.4%)
  4+94 (8.6%)20 (10.0%)56 (8.4%)18 (8.2%)
  Missing (n)2110
 Histologic grade
  1266 (24.4%)43 (21.3%)167 (25.0%)56 (25.5%)>0.3b
  2540 (49.6%)110 (54.5%)324 (48.6%)106 (48.2%)
  3283 (26.0%)49 (24.3%)176 (26.4%)58 (26.4%)
  Missing (n)1010
 Ki67
  Negative/low (≤20%)300 (63.0%)63 (63.0%)173 (62.0%)64 (66.0%)>0.3b
  High (>20%)176 (37.0%)37 (37.0%)106 (38.0%)33 (34.0%)
  Missing (n)614102389123
 Hormone receptor status
  ER+956 (87.9%)185 (91.6%)586 (88.1%)185 (84.1%)0.018b
  ER131 (12.1%)17 (8.4%)79 (11.9%)35 (15.9%)
  Missing (n)3030
  PgR+774 (71.2%)139 (68.8%)483 (72.6%)152 (69.1%)>0.3b
  PgR313 (28.8%)63 (31.2%)182 (27.4%)68 (30.9%)
  Missing (n)3030
  ER+PgR+767 (70.6%)138 (68.3%)479 (72%)150 (68.2%)>0.3b
  ER+PgR189 (17.4%)47 (23.3%)107 (16.1%)35 (15.9%)0.052b
  ERPgR124 (11.4%)16 (7.9%)75 (11.3%)33 (15.0%)0.022b
  ERPgR+7 (0.6%)1 (0.5%)4 (0.6%)2 (0.9%)>0.3b
  Missing (n)3030
  • aThe Jonckheere–Terpstra test.

  • bThe linear-by-linear association test.