Table 3.

Comparison of clinical characteristics of MAP2K1 (MEK1)-mutant patients versus other molecularly defined subsets

MAP2K1 (n = 36)KRAS (n = 1,254)aEGFR (n = 769)a
Gender (female/male)18/18788/466 (P = 0.07)546/223 (P = 0.006)
Median age (range)68 (48–89)68 (37–90)67 (30–92)
Smoking status (former or current/never smoker)35/11136/118 (P = 0.36)347/422 (<0.00001)

NOTE: P values in parentheses are based on comparison with MEK1.

  • aKRAS and EGFR groups are based on the MSKCC cohort.