Table 1.

Phenotypes of manufactured lymphocytes after TCR gene transduction

MAGE-A4 tetramer+ cellsIFNγ responded cellsa
Patient IDCD3 (%)CD4 (%)CD8 (%)CD8 cells (%)CD8+ cells (%)CD8 cells (%)CD8+ cells (%)Copies of TCR transgene/cell
TCR-MA-10289.459.930.34.56.36.624.35.4
TCR-MA-10491.871.727.10.51.85.523.15.1
TCR-MA-10696.729.376.80.38.63.69.76.9
TCR-MA-20895.581.117.68.54.122.438.910.0
TCR-MA-20997.957.545.42.67.921.828.88.8
TCR-MA-21094.740.960.53.311.17.315.98.3
TCR-MA-21299.714.188.90.612.67.529.610.1
TCR-MA-21395.647.254.12.89.19.119.69.9
TCR-MA-31497.641.159.91.01.54.922.17.1
TCR-MA-31589.854.145.32.64.518.243.18.7
  • aIFNγ releasing cells responded by peptide-pulsed target cells.