Table 2.

Concordance between CTC and tissue biomarker expression

Primary tissueMetastatic tissue
PositiveaNegativeTotalPositiveaNegativeTotal
A. ER
CTC
 Positiveb10010426
 Negative909729
 Total1901911415
B. BCL-2
CTC
 Positive121138210
 Negative314123
 Total152179413
C. HER2
CTC
 Positive527347
 Negative5813628
 Total1010209615
D. Ki67
CTC
 Positive414186814
 Negative022112
 Total416207916
  • aFor tissue ER and BCL-2, positive = Allred Score ≥3; for HER2, positive = Allred score ≥4; for Ki67, positive = ≥10% staining

  • bFor CTC-ER, BCL-2, HER2, and Ki67, positive = ≥10% staining 2-3 in sample with ≥1CTC/7.5 ml of WB.