Table 2.

HRs (95% CI) and χ2 values for all individual genes and gene modules according to time periods in HER2 patients

0–10 years0–5 years5–10 years
HR (95% CI)LR-χ2HR (95% CI)LR-χ2HR (95% CI)LR-χ2Pheterogeneity
HER2 genes
 GRB70.79 (0.64–0.97)4.910.71 (0.52–0.97)4.560.79 (0.59–1.06)2.490.6
 HER20.90 (0.73–1.11)0.940.70 (0.51–0.96)4.891.01 (0.75–1.36)0.010.09
 HER module0.79 (0.63–0.98)4.640.69 (0.50–0.95)4.870.80 (0.59–1.08)2.120.5
 HER module (with threshold)0.89 (0.50–1.60)0.150.44 (0.14–1.42)2.311.17 (0.58–2.38)0.19
Proliferation genes
 Cyclin B11.85 (1.51–2.26)35.541.81 (1.32–2.47)13.851.81 (1.37–2.39)17.960.9
 Ki-671.64 (1.40–1.91)42.011.52 (1.19–1.93)12.311.66 (1.35–2.04)24.630.6
 MYLB21.51 (1.34–1.70)44.921.59 (1.32–1.91)23.11.46 (1.24–1.71)20.450.5
 STK151.95 (1.61–2.36)40.942.02 (1.49–2.73)18.421.83 (1.41–2.39)180.6
 Survivin1.45 (1.29–1.64)37.711.50 (1.24–1.81)18.051.42 (1.21–1.66)18.190.6
 Proliferation module1.90 (1.60–2.27)531.94 (1.47–2.56)22.711.84 (1.45–2.33)26.110.8
 Proliferation module (with threshold)2.86 (1.84–4.43)17.133.18 (1.68–6.05)9.582.72 (1.46–5.06)7.85
Estrogen genes
 BCL20.61 (0.52–0.71)35.830.57 (0.45–0.73)19.860.64 (0.52–0.81)14.520.5
 SCUBE20.96 (0.88–1.04)0.940.84 (0.74–0.96)6.671.07 (0.94–1.20)1.10.009
 ER1.05 (0.92–1.20)0.510.88 (0.73–1.07)1.611.19 (0.99–1.43)3.540.03
 PgR0.94 (0.87–1.01)2.620.86 (0.76–0.96)6.871.00 (0.90–1.11)0.0010.05
 Estrogen module0.83 (0.72–0.96)6.130.66 (0.54–0.81)14.411.01 (0.82–1.23)0.0010.004
Invasion genes
 Cathepsin L21.26 (1.07–1.48)7.61.19 (0.93–1.54)1.841.27 (1.02–1.59)4.620.7
 Stromelysin 31.25 (1.12–1.39)16.351.30 (1.09–1.55)9.241.23 (1.06–1.42)7.710.6
 Invasion module1.56 (1.30–1.87)23.391.60 (1.20–2.14)10.671.53 (1.20–1.96)11.930.8
Other genes
 BAG10.73 (0.58–0.90)8.920.52 (0.36–0.73)14.790.85 (0.64–1.13)1.280.03
 CD681.03 (0.80–1.32)0.041.08 (0.73–1.60)0.151.03 (0.73–1.45)0.030.9
 GSTM10.77 (0.68–0.87)17.120.73 (0.61–0.87)11.250.80 (0.68–0.95)6.290.4
RS1.033 (1.022–1.045)27.021.045 (1.028–1.062)23.451.024 (1.007–1.042)6.740.09