Table 2.

Association of CTC enumeration, apoptosis, and clusters with outcomes

Baseline
CTC enumeration a CTC apoptosis b CTC clusters c
ORRPCBRPPFSPORRPCBRPPFSPORRPCBRPPFSP
No12/33 (36.4)0.2523/33 (69.7)0.0213.60.0053/14 (21.4)1.06/14 (42.9)0.601.90.475/24 (20.8)1.011/24 (45.8)1.02.30.34
Yes4/19 (21.1)7/19 (36.8)1.91/5 (20.0)1/5 (20.0)2.11/8 (12.5)3/8 (37.5)2.0
Day 15
CTC enumeration a CTC apoptosis b CTC clusters c
ORR P CBR P PFS P ORR P CBR P PFS P ORR P CBR P PFS P
No14/38 (36.8)0.3426/38 (68.4)0.0103.60.00032/7 (28.6)1.02/7 (28.6)1.01.80.115/18 (27.8)0.547/18 (38.9)0.262.50.028
Yes3/14 (21.4)4/14 (28.6)1.91.7 (14.3)2/7 (28.6)2.10/4 (0)0/4 (0)1.8
Day 29
CTC enumeration a CTC apoptosis b CTC clusters c
ORR P CBR P PFS P ORR P CBR P PFS P ORR P CBR P PFS P
No14/36 (38.9)0.04327/36 (75.0)0.00023.70.00020/5 (0)1.01/5 (20.0)1.01.80.734/12 (33.3)0.256/12 (50.0)0.0442.70.009
Yes1/13 (7.7)2/13 (15.4)1.91/8 (12.5)1/8 (12.5)2.00/7 (0)0/7 (0)1.8

NOTE: Values in parentheses are numbers expressed in %. PFS is median time to progression in months.

  • aFor CTC enumeration: No, <5 CTC/7.5 mL; Yes, ≥5 CTC/7.5 mL.

  • bFor CTC apoptosis: No, ≥5 CTC/7.5 mL with <25% apoptotic; Yes, ≥5 CTC/7.5 mL with ≥25% apoptotic.

  • cCTC clusters: No, ≥1 CTC/7.5 mL with no cluster; Yes, ≥1 CTC with at least 1 cluster.