Table 2.

Dose escalation and DLTs

ScheduleDose level (mg/kg)Patients, nDLTsDLT eventCycles median, n (range)
Q3W0.25702 (1–4)
0.561Grade 3 nausea3 (1–18)
1605 (2–6)
2603 (2–7)
4603 (3–4)
Q2W0.75603 (1–4)
17 a 1Grade 3 abdominal pain2 (0–9)
1.5304 (1–6)
3602 (1–9)
  • aOne patient was replaced.