Table 5.

PK parameters after multiple doses of BI-505, two-compartmental model

ParameterUnit10 mg/kg (Nobs = 5)20 mg/kg (Nobs = 3)
AUC0–∞ μg × h/mL14,200 (31.9)70,000 (56.9)
C max μg/mL179 (43.2)479 (12.0)
t 1/2 a h97.0 (34.3)341 (83.2)
CLmL/h/kg0.703 (28.4)0.286 (43.4)
V ss mL/kg89.4 (36.0)139 (16.5)

Abbreviations: CL, total systemic clearance; N obs, number of observations used in the calculation; V ss, volume of distribution at steady state.

  • a t 1/2, harmonic mean.