Table 1.

Multivariate Cox regression analysis for DFS and OS of the pathologic and immune variables in primary and metastatic ccRCC

Multivariate Cox regression analysis DFSMultivariate Cox regression analysis OS
Primary ccRCCHR (95% CI)(lower–upper)PHR (95% CI)(lower–upper)P
CD8high TLS-DClow (yes vs. no)3.19 (1.42–3.83)0.0011.57 (0.45–1.82)0.41
PD-L1 or L2 5%–100% + PD-1high (yes vs. no)1.88 (1.56–2.89)0.032.22 (0.80–1.16)0.24
Fuhrman grade1.90 (0.99–2.00)0.062.68 (0.99–2.16)0.32
TNM stage (I–IV)1.59 (0.18–2.33)0.122.74 (1.01–3.05)0.002
Multivariate Cox regression analysis OS
Metastatic ccRCCHR (95% CI)(lower–upper)P
CD8 group (high vs. low)2.86 (1.21–3.11)0.004
PD-L1 or L2 5%–100% + PD-1high (yes vs. no)1.41 (1.19–2.48)0.02
Lymph node invasion (yes vs. no)0.72 (0.35–1.42)0.47