Table 2.

All-grade adverse reactions in ≥20% of patients or grade 3/4 adverse reactions in ≥5% of patients in either study

MCL (N = 111)CLL (N = 48)
System organ classAll gradesGrades 3/4All gradesGrades 3/4
Preferred term%%%%
Gastrointestinal disorders
 Abdominal pain245150
Infections and infestations
 Upper respiratory tract infection340482
 Skin infection145176
General disorders and administrative site conditions
 Peripheral edema353230
Musculoskeletal and connective tissue disorders
 Musculoskeletal pain371276
Skin and subcutaneous tissue disorders
Respiratory, thoracic, and mediastinal disorders
Metabolism and nutrition disorders
 Decreased appetite212172
Nervous system disorders
Cardiac disorders
 Atrial fibrillation86198
Vascular disorders
Hematology laboratory abnormalities
 Platelets decreased57177110
 Neutrophils decreased47295427
 Hemoglobin decreased419440