Per allele model assuming no interaction | ||
---|---|---|

Covariate | HR (95% CI) | P |

Per-allele rs8113308 | 1.27 (1.02–1.59) | 3.61 × 10^{−2} |

Endocrine | 0.59 (0.44–0.80) | 6.76 × 10^{−4} |

PR | 0.60 (0.46–0.78) | 1.68 × 10^{−4} |

T | 1.45 (1.27–1.67) | 8.89 × 10^{−8} |

N | 2.14 (1.61–2.85) | 1.92 × 10^{−7} |

M | 1.60 (1.02–2.51) | 3.91 × 10^{−2} |

Grade | 1.52 (1.25–1.84) | 2.32 × 10^{−5} |

Per allele model including per allele SNP:endocrine interaction term | ||

Covariate | HR (95% CI) | P |

Per-allele rs8113308 | 0.75 (0.49–1.17) | 2.06 × 10^{−1} |

Endocrine | 0.22 (0.11–0.45) | 2.65 × 10^{−5} |

PR | 0.58 (0.45–0.76) | 6.80 × 10^{−5} |

T | 1.44 (1.25–1.65) | 2.47 × 10^{−7} |

N | 2.12 (1.59–2.82) | 2.76 × 10^{−7} |

M | 1.62 (1.04–2.54) | 3.40 × 10^{−2} |

Grade | 1.52 (1.25–1.85) | 2.31 × 10^{−5} |

Per-allele rs8113308:Endocrine | 2.16 (1.30–3.60) | 3.13 × 10^{−3} |

Likelihood ratio test P value | 0.0021 | |

Codominant model assuming no interaction | ||

Covariate | HR (95% CI) | P |

rs8113308 A/G | 1.22 (0.93–1.60) | 1.49 × 10^{−1} |

rs8113308 G/G | 1.87 (0.96–3.66) | 6.79 × 10^{−2} |

Endocrine | 0.56 (0.44–0.80) | 6.56 × 10^{−4} |

PR | 0.60 (0.46–0.78) | 1.66 × 10^{−4} |

T | 1.46 (1.27–1.67) | 8.13 × 10^{−8} |

N | 2.13 (1.60–2.84) | 2.25 × 10^{−7} |

M | 1.60 (1.02–2.50) | 4.06 × 10^{−2} |

Grade | 1.52 (1.25–1.84) | 2.31 × 10^{−5} |

Codominant model including per genotype SNP:endocrine interaction term | ||

Covariate | HR (95% CI) | P |

rs8113308 A/G | 0.79 (0.48–1.28) | 3.34 × 10^{−1} |

rs8113308 G/G | 0.41 (0.06–2.98) | 3.78 × 10^{−1} |

Endocrine | 0.49 (0.35–0.68) | 1.93 × 10^{−5} |

PR | 0.58 (0.44–0.76) | 6.27 × 10^{−5} |

T | 1.43 (1.25–1.65) | 3.80 × 10^{−7} |

N | 2.12 (1.59–2.82) | 2.82 × 10^{−7} |

M | 1.65 (1.05–2.59) | 2.94 × 10^{−2} |

Grade | 1.52 (1.25–1.84) | 2.37 × 10^{−5} |

rs8113308A/G:Endocrine | 1.95 (1.08–3.49) | 2.58 × 10^{−2} |

rs8113308G/G:Endocrine | 7.77 (0.93–64.71) | 5.79 × 10^{−2} |

Likelihood ratio test P value | 0.0078 |

NOTE: The model was stratified by study and adjusted by age and used 10-year breast cancer–specific survival and included ER-positive cases only; per allele model assuming no interaction and per allele model including per allele SNP:endocrine interaction term. Likelihood ratio test *P* = 0.0021. Codominant model assuming no interaction and codominant model including per genotype SNP:endocrine interaction term. Likelihood ratio test *P* = 0.0078.