Table 3.

The Cox proportional hazards models to test for interaction between endocrine treatment and rs8113308 in the pooled dataset of HEBCS and POSH GWS and POSH validation

Per allele model assuming no interaction
CovariateHR (95% CI)P
Per-allele rs81133081.27 (1.02–1.59)3.61 × 10−2
Endocrine0.59 (0.44–0.80)6.76 × 10−4
PR0.60 (0.46–0.78)1.68 × 10−4
T1.45 (1.27–1.67)8.89 × 10−8
N2.14 (1.61–2.85)1.92 × 10−7
M1.60 (1.02–2.51)3.91 × 10−2
Grade1.52 (1.25–1.84)2.32 × 10−5
Per allele model including per allele SNP:endocrine interaction term
CovariateHR (95% CI)P
Per-allele rs81133080.75 (0.49–1.17)2.06 × 10−1
Endocrine0.22 (0.11–0.45)2.65 × 10−5
PR0.58 (0.45–0.76)6.80 × 10−5
T1.44 (1.25–1.65)2.47 × 10−7
N2.12 (1.59–2.82)2.76 × 10−7
M1.62 (1.04–2.54)3.40 × 10−2
Grade1.52 (1.25–1.85)2.31 × 10−5
Per-allele rs8113308:Endocrine2.16 (1.30–3.60)3.13 × 10−3
Likelihood ratio test P value0.0021
Codominant model assuming no interaction
CovariateHR (95% CI)P
rs8113308 A/G1.22 (0.93–1.60)1.49 × 10−1
rs8113308 G/G1.87 (0.96–3.66)6.79 × 10−2
Endocrine0.56 (0.44–0.80)6.56 × 10−4
PR0.60 (0.46–0.78)1.66 × 10−4
T1.46 (1.27–1.67)8.13 × 10−8
N2.13 (1.60–2.84)2.25 × 10−7
M1.60 (1.02–2.50)4.06 × 10−2
Grade1.52 (1.25–1.84)2.31 × 10−5
Codominant model including per genotype SNP:endocrine interaction term
CovariateHR (95% CI)P
rs8113308 A/G0.79 (0.48–1.28)3.34 × 10−1
rs8113308 G/G0.41 (0.06–2.98)3.78 × 10−1
Endocrine0.49 (0.35–0.68)1.93 × 10−5
PR0.58 (0.44–0.76)6.27 × 10−5
T1.43 (1.25–1.65)3.80 × 10−7
N2.12 (1.59–2.82)2.82 × 10−7
M1.65 (1.05–2.59)2.94 × 10−2
Grade1.52 (1.25–1.84)2.37 × 10−5
rs8113308A/G:Endocrine1.95 (1.08–3.49)2.58 × 10−2
rs8113308G/G:Endocrine7.77 (0.93–64.71)5.79 × 10−2
Likelihood ratio test P value0.0078

NOTE: The model was stratified by study and adjusted by age and used 10-year breast cancer–specific survival and included ER-positive cases only; per allele model assuming no interaction and per allele model including per allele SNP:endocrine interaction term. Likelihood ratio test P = 0.0021. Codominant model assuming no interaction and codominant model including per genotype SNP:endocrine interaction term. Likelihood ratio test P = 0.0078.