Table 1.

Patient characteristics

VariableDefinitionn (%)
Number of patientsSMZL diagnosis175 (100%)
Age at diagnosis, yMean (range)68 (36–90)
IGHV genesIGHV1-2*0416 (13%)
not IGHV1-2*04108 (87%)
del(7q) status from karyotypedel(7q)17 (19%)
Normal74 (81%)
Surface CD5 FACS resultCD5+40 (27%)
CD5108 (73%)
White blood cellMean (range) (×109/L)20 (0.5–158)
Hemoglobin<12 g/dL73 (44%)
≥12 g/dL93 (56%)
Lymphocyte count<4 × 109/L41 (27%)
≥4 × 109/L110 (73%)
Platelets < 100 × 109/L<100 × 109/L30 (18%)
≥100 × 109/L134 (82%)
High-risk FISH resultsdel(17p)10 (33%)
Normal20 (67%)
SplenectomyYes55 (34%)
No109 (67%)
Transformation to large cell lymphomaYes19 (17%)
No91 (83%)
TTFT statusTreated (inc. splenectomy)122 (74%)
Untreated42 (26%)
EFS statusEvent (death, transformation, second treatment)52 (44%)
No event65 (56%)
Status (alive or dead at last follow-up)Dead43 (25%)
Alive126 (75%)

NOTE: Complex Karyotype was defined as ≥2 cytogenetically visible clonal alterations.