Table 2.

Univariate survival analysis of recurrently mutated genes

	Variable	Description	Total	Events	Median, y (95% CI)	HR (95% CI)	P
TTFT	KLF2	Mutated	20	18	0.12 (0.0–0.24)	1.93 (1.16–3.23)	0.01
		Unmutated	140	100	1.11 (0.0–2.28)
	NOTCH2	Mutated	17	17	0.09 (0.0–0.22)	2.13 (1.26–3.58)	0.003
		Unmutated	143	101	0.94 (0.0–2.03)
	Hb	<12 g/dL	70	63	0.1 (0.04–0.17)	2.75 (1.87–4.02)	<0.001
		>12 g/dL	84	51	2.73 (0.0–7.14)
	Lymphocytes	<4 × 10⁹/l	40	33	0.15 (0.07–0.24)	1.76 (1.16–2.68)	0.007
		>4 × 10⁹/l	101	69	1.43 (0.50–2.37)
	IGHV identity	100%	12	11	0.14 (0.0–0.38)	2.06 (1.07–3.74)	0.027
		<100%	78	50	1.98 (0.98–2.99)
EFS	TP53	Mutated	15	8	0.98 (0.04–12.22)	2.17 (1.00–4.74)	0.05
		Unmutated	84	32	3.11 (2.35–6.20)
	Age	>65 y	53	26	6.82^a (4.45–9.20)	2.09 (1.07–4.08)	0.028
		<65 y	45	14	12.69^a (9.19–16.18)
	Platelet count	<100 × 10⁹/L	19	11	2.92 (2.03–3.80)	1.99 (0.98–4.02)	0.052
		>100 × 10⁹/L	78	28	6.91 (4.47–9.34)
OS	TP53	Mutated	26	10	12.21 (5.28–19.14)	2.16 (1.05–4.43)	0.032
		Unmutated	134	33	16.03 (14.64–17.43)
	MYD88	Mutated	12	0	—^b	—^c	0.02^d
		Unmutated	148	43	—
	Age	>65 y	103	37	10.36^a (9.0–11.76)	6.37 (2.55–15.87)	<0.001
		<65 y	56	6	22.65^a (19.38–25.91)
	Hb	<12 g/dL	68	24	9.01 (2.90–15.12)	2.69 (1.45–4.99)	0.001
		>12 g/dL	87	18	16.35 (14.99–17.70)

Log-rank P values.

↵^aMean survival value as median not reached.
↵^bNo events in MYD88 mutated cases and median survival times not presented, follow-up time ranged from 1.25 to 19.9 years.
↵^cHR and 95% CI cannot be reliable calculated as there are no events in MYD88 mutated group.
↵^dLog-rank P value for χ² value reported for the MYD88 OS Kaplan–Meier analysis (see Fig. 3E).