Table 2.

Univariate survival analysis of recurrently mutated genes

VariableDescriptionTotalEventsMedian, y (95% CI)HR (95% CI)P
TTFTKLF2Mutated20180.12 (0.0–0.24)1.93 (1.16–3.23)0.01
Unmutated1401001.11 (0.0–2.28)
NOTCH2Mutated17170.09 (0.0–0.22)2.13 (1.26–3.58)0.003
Unmutated1431010.94 (0.0–2.03)
Hb<12 g/dL70630.1 (0.04–0.17)2.75 (1.87–4.02)<0.001
>12 g/dL84512.73 (0.0–7.14)
Lymphocytes<4 × 109/l40330.15 (0.07–0.24)1.76 (1.16–2.68)0.007
>4 × 109/l101691.43 (0.50–2.37)
IGHV identity100%12110.14 (0.0–0.38)2.06 (1.07–3.74)0.027
<100%78501.98 (0.98–2.99)
EFSTP53Mutated1580.98 (0.04–12.22)2.17 (1.00–4.74)0.05
Unmutated84323.11 (2.35–6.20)
Age>65 y53266.82a (4.45–9.20)2.09 (1.07–4.08)0.028
<65 y451412.69a (9.19–16.18)
Platelet count<100 × 109/L19112.92 (2.03–3.80)1.99 (0.98–4.02)0.052
>100 × 109/L78286.91 (4.47–9.34)
OSTP53Mutated261012.21 (5.28–19.14)2.16 (1.05–4.43)0.032
Unmutated1343316.03 (14.64–17.43)
MYD88Mutated120bc0.02d
Unmutated14843
Age>65 y1033710.36a (9.0–11.76)6.37 (2.55–15.87)<0.001
<65 y56622.65a (19.38–25.91)
Hb<12 g/dL68249.01 (2.90–15.12)2.69 (1.45–4.99)0.001
>12 g/dL871816.35 (14.99–17.70)

Log-rank P values.

  • aMean survival value as median not reached.

  • bNo events in MYD88 mutated cases and median survival times not presented, follow-up time ranged from 1.25 to 19.9 years.

  • cHR and 95% CI cannot be reliable calculated as there are no events in MYD88 mutated group.

  • dLog-rank P value for χ2 value reported for the MYD88 OS Kaplan–Meier analysis (see Fig. 3E).