Table 1.

Summary of baseline characteristics by histologic subtype and race

ParameterHyaline vascular (n = 26)Plasmacytic (n = 18)Mixed (n = 35)Asian (n = 38)Non-Asian (n = 41)
Age, y
n2618353841
 Mean (SD)39.35 (12.00)45.22 (14.36)50.20 (12.17)45.21 (13.42)45.76 (13.45)
 Median (range)35.5 (25.0–63.0)46.5 (20.0–70.0)49.0 (26.0–78.0)47.5 (20.0–74.0)48.0 (20.0–78.0)
Height, cm
n2618353841
 Mean (SD)171.39 (10.51)167.71 (7.11)166.72 (9.22)166.67 (7.90)170.16 (10.37)
 Median (range)174.5 (151.0–190.5)168.3 (152.0–177.8)169.0 (147.5–187.0)167.8 (147.5–180.0)171.8 (148.0–190.5)
IL6, pg/mL
n2416353738
 Mean (SD)4.64 (2.95)14.24 (14.98)8.38 (7.15)9.30 (7.89)7.58 (10.26)
 Median (range)4.55 (0.38–9.77)7.59 (2.09–50.64)7.69 (0.43–32.46)7.62 (0.38–32.46)4.94 (0.55–50.64)
CRP, mg/L
n2618353841
 Mean (SD)30.67 (45.96)62.92 (57.16)28.65 (42.47)48.11 (52.11)26.94 (43.57)
 Median (range)9.76 (0.8–181.00)37.75 (1.19–148.00)5.09 (0.1–170.0)27.6 (0.1–170.0)4.93 (0.39–181.0)
Hepcidin, ng/mL
n2517353839
 Mean (SD)135.96 (143.25)152.56 (136.26)147.51 (141.35)168.28 (148.40)122.07 (127.34)
 Median (range)121.9 (9.5–665.5)141.0 (9.5–538.0)116.0 (9.5–762.4)136.7 (9.5–762.4)84.5 (9.5–665.5)
Serum creatinine, μmol/L
n2618353841
 Mean (SD)74.24 (14.50)84.40 (38.21)79.73 (22.12)77.94 (28.09)79.95 (21.55)
 Median (range)74.5 (50.4–114.0)75.3 (42.1–168.0)77.0 (48.0–164.0)74.75 (42.1–164.0)77.0 (50.4–168.0)
Hemoglobin, g/L
n2618353841
 Mean (SD)128.41 (20.42)103.83 (26.31)123.11 (25.80)117.18 (26.93)123.50 (24.53)
 Median (range)134.0 (69.0–116.0)103.5 (65.0–181.0)124.0 (81.0–170.0)118.0 (65.0–170.0)131.0 (69.0–181.0)
TIBC, μmol/L
n2217353836
 Mean (SD)51.55 (14.08)48.67 (26.78)48.66 (18.70)46.20 (22.51)53.02 (15.17)
 Median (range)53.01 (20.0–77.37)41.73 (21.0–133.35)44.60 (21.49–95.67)40.66 (20.0–133.35)50.86 (28.48–95.67)
Iron, μmol/L
n2617353840
 Mean (SD)9.58 (5.36)7.37 (4.69)9.54 (4.63)8.17 (4.92)9.95 (4.82)
 Median (range)9.93 (2.86–21.03)5.90 (1.97–18.62)8.60 (2.51–23.20)6.45 (2.51–23.20)10.92 (1.97–21.30)
Platelets, ×109/L
n2618353841
 Mean (SD)301.65 (167.25)376.67 (147.49)296.37 (122.43)337.24 (154.49)297.10 (136.84)
 Median (range)243.5 (79.0–692.0)343.5 (203.0–686.0)268.0 (73.0–579.0)289.5 (73.0–686.0)243.0 (118.0–692.0)
TSAT, fraction
n2317333835
 Mean (SD)0.19 (0.10)0.15 (0.07)0.22 (0.10)0.19 (0.09)0.20 (0.10)
 Median (range)0.16 (0.06–0.42)0.16 (0.05–0.26)0.22 (0.07–0.48)0.18 (0.06–0.48)0.21 (0.05–0.42)
WBC, ×109/L
n2618353841
 Mean (SD)7.54 (3.90)7.98 (2.64)7.46 (3.22)6.87 (2.47)8.28 (3.84)
 Median (range)6.73 (2.70–21.10)7.85 (3.87–13.73)6.80 (2.30–17.88)6.61 (3.00–16.20)7.50 (2.30–21.10)

NOTE: Baseline data are shown for the ITT population.

Abbreviations: ITT, intent-to-treat; TIBC, total iron-binding capacity; TSAT, transferrin saturation; WBC, white blood cells.