Table 1.

IPA pathways regulated by lovastatin in ovarian cancer cells

Ingenuity canonical pathways−log (P)RatioMolecules
Cell cycle control of chromosomal replication5.38E+002.35E−01MCM5, MCM3, MCM6, MCM2, CDT1, CDC6, ORC6, MCM4
PLC signaling3.23E+007.17E−02ARHGEF4, PLD3, RRAS, PLA2G4C, MEF2A, ITGA5, CREB5, HMOX1, PLCB4, RHOB, AHNAK, RHOA, ARHGEF6, LAT, ITPR3, ARHGEF2, ARHGEF3, RHOF, RALGDS
Role of tissue factor in cancer3.21E+009.23E−02VEGFA, IL8, CTGF, ARRB1, RRAS, ITGA6, IL1B, CSF2, CYR61, ITGB5, MMP1, ITGB3
Bile acid biosynthesis, neutral pathway2.98E+006.90E−02AKR1C1/AKR1C2, AKR1C3, AKR1C4, HSD3B7
VDR/RXR activation2.66E+001.02E−01IGFBP6, SPP1, MXD1, CDKN1A, HES1, CEBPB, THBD, CSF2, NCOA3
Glioma invasiveness signaling2.30E+001.06E−01RHOB, RRAS, RHOA, PLAU, RHOF, ITGB5, ITGB3
Methylglyoxal degradation III2.17E+001.30E−01AKR1C1/AKR1C2, AKR1C3, AKR1C4
Dopamine degradation2.16E+001.05E−01ALDH1B1, SULT1A1, SULT1A3/SULT1A4, SMOX
Androgen biosynthesis2.06E+001.15E−01AKR1C3, AKR1C4, HSD3B7
Reelin signaling in neurons2.05E+009.41E−02ARHGEF4, MAPT, ARHGEF6, ITGA6, ITGA5, ARHGEF2, ARHGEF3, ITGB3
IL17A signaling in fibroblasts2.04E+001.25E−01TRAF3IP2, NFKBIA, LCN2, CEBPB, MMP1
Estrogen-mediated S-phase entry1.95E+001.43E−01CDKN1A, E2F2, SKP2, CDC25A