Table 1.

Clinical trials with Smac mimetics

CompoundCombinationCancer typeStatusPhase I/IIReference
LCL-161NoneSolid tumorsCompletedPhase INCT01098838
LCL-161NoneLeukemiaRecruitingPhase IINCT02098161
LCL-161PaclitaxelSolid tumorsCompletedPhase INCT01240655
LCL-161PaclitaxelSolid tumorsRecruitingPhase INCT01968915
LCL-161PaclitaxelBreast cancerCompletedPhase IINCT01617668
LCL-161GemcitabinePancreatic cancerRecruitingPhase INCT01934634
LCL-161CyclophosphamideMultiple myelomaRecruitingPhase IINCT01955434
GDC-0152NoneSolid cancersCompletedPhase INCT00977067
CUCD-427NoneLymphomaRecruitingPhase INCT01908413
BirinapantNoneSolid tumorsCompletedPhase I/IINCT01188499
BirinapantNoneSolid tumors, lymphomaCompletedPhase INCT00993239
BirinapantNoneAMLCompletedPhase I/IINCT01486784
BirinapantNoneOvarian, peritoneal and fallopian tube cancerCompletedPhase IINCT01681368
BirinapantGemcitabineSolid tumorsTerminatedPhase INCT01573780
Birinapant5-AzaMDSActive, not recruitingPhase I/IINCT01828346
Birinapant5-AzaMDS, CMMLRecruitingPhase IINCT02147873
BirinapantConatumumabOvarian, peritoneal and fallopian tube cancerRecruitingPhase INCT01940172
AT-406Daunorubicin, cytarabineAMLTerminatedPhase INCT01265199
Debio1143NoneSolid tumors, lymphomaCompletedPhase INCT01078649
Debio1143Paclitaxel, carboplatinSolid tumorsRecruitingPhase INCT01930292
Debio1143Cisplatin, radiotherapyHead and neck carcinomaRecruitingPhase I/IINCT02022098
HGS1029NoneSolid tumorsCompletedPhase INCT00708006
HGS1029NoneLymphoid malignanciesTerminatedPhase INCT01013818

Abbreviations: 5-Aza, 5-Azacitidine; AML; acute myelogenous leukemia; CMML, chronic myelomonocytic leukemia; MDS, myelodysplastic syndrome.