Table 1.

Characteristics of melanoma patients treated with ipilimumab

Variablesn (%)
Patients59
Median age (range)65.2 (32–84)
Sex
 Male36 (61)
 Female23 (39)
Primary melanoma site
 Cutaneous40 (68)
 Mucosal1 (2)
 Uveal6 (10)
 Occult7 (12)
 Unclassified5 (8)
AJCC stage
 IV59 (100)
 M1a1 (2)
 M1b13 (22)
 M1c45 (76)
 CNS metastases at baseline18 (30)
 Prior surgery for CNS metastases5 (8)
 Prior radiotherapy for CNS metastases11 (18)
 Lactate dehydrogenase level above the ULN19 (32)
Prior therapy
N = 011
N = 124
N = 215
N = 35
N ≥ 44
 Cytotoxic chemotherapy39 (66)
 Radiotherapy28 (47)
 Adjuvant therapy29 (49)
Other therapies
 BRAF + MEK inhibitor8 (14)
 Imatinib (tyrosine kinase inhibitor)1 (2)

Abbreviations: CNS, central nervous system; ULN, upper limit of normal.