Table 2.

Treatment-related adverse events

Adverse eventAny grade, n (%)Grades 3–4, n (%)
Rash35 (76%)10 (22%)
Diarrhea35 (76%)6 (13%)
Nausea/vomiting27 (59%)4 (9%)
Fatigue26 (57%)3 (7%)
AST/ALT elevation22 (48%)4 (9%)
Anorexia15 (33%)0 (0%)
Anemia14 (30%)5 (11%)
Dysgeusia11 (24%)0 (0%)
Eye disordersa9 (20%)0 (0%)
Pruritus9 (20%)0 (0%)
Hypertension8 (17%)6 (13%)
Thrombocytopenia5 (11%)1 (2%)
Leukopenia/neutropenia4 (9%)1 (2%)
Thromboembolic eventb4 (9%)3 (7%)
Elevated creatinine4 (9%)0 (0%)
  • aIncluding blurry vision, eye pain, floaters, and dry or watery eyes.

  • bIncluding cerebrovascular event (1).