Table 4.

Gene-level relationships with lethal outcome, in logistic regression models including all genes in the pathway, as well as age at diagnosis and cohort membership as control covariatesa

AdrenergicORsPGlucocorticoidORsPSerotoninergicORsPMuscarinicORsP
ADRA1A0.210.0004FKBP41.20.63HTR1A0.50.19CHRM10.290.0001
ADRA1B0.980.97HSP90AA12.00.090HTR1B0.280.074CHRM21.30.70
ADRA1D0.330.031HSP90AB12.10.057HTR1D2.30.14CHRM30.930.68
ADRA2A1.10.87HSPA1A0.400.11HTR1E0.990.99CHRM41.00.94
ADRA2B0.980.97HSPA1B1.60.42HTR1F0.700.55CHRM51.00.95
ADRA2C0.410.15HSPA40.510.12HTR2A4.10.027
ADRB10.610.30NR3C11.50.37HTR2B4.00.0047
ADRB20.780.52POU2F14.90.015HTR2C0.440.23
ADRB30.750.55POU2F20.740.69HTR3A1.40.55
ADRBK10.480.046PTGES36.5<0.0001HTR3B2.80.088
ADRBK20.760.33SMAD30.750.56HTR3C0.970.96
SMAD40.17<0.0001HTR3D0.490.24
HTR3E2.80.085
HTR40.790.75
HTR5A0.530.24
HTR60.310.024
HTR70.650.47
  • aOR > 1 indicates overexpression of the gene, whereas OR < 1 indicates underexpression.