Table 1.

irAEs by cohort and grade

irAECohortGrade I–II, n (% of subgroup)Grade III, n (% of subgroup)
RashUnresectable46 (40)2 (1.7)
Resected18 (54.6)1 (3)
Diarrhea/colitis/enteritisUnresectable34 (22.9)
Resected14 (42.4)2 colitis (6.1)
VitiligoUnresectable11 (9.6)
Resected8 (24.2)
HypothyroidismUnresectable10 (8.7)
Resected6 (21.2)
Elevated amylase/lipaseUnresectable
Resected5 (15.1)2 (6.1)
MucositisUnresectable3 (2.6)
Resected6 (18.2)
PneumonitisUnresectable3 (2.6)
Resected
HyperthyroidismUnresectable2 (1.7)
Resected
HypophysitisUnresectable
Resected1 (3)
Elevated ALT/ASTUnresectable
Resected1 (3)

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.