Table 2.

Timing of onset and resolution for irAEs

irAEn (%)Median weeks to onsetMedian weeks to resolutionSystemic steroid therapyMedian weeks of steroid therapy
Elevated amylase/lipase7 (4.7)216
Elevated ALT/AST1 (0.7)26
Diarrhea/enteritis48 (32.4)4.21.3Yes5
Colitis2 (1.4)5.34Yes5
Rash64 (43.2)5.66.4
Vitiligo19 (12.8)5.4
Hyperthyroidisma2 (1.4)9.111.3
Hypophysitis1 (0.7)20.313.8
Mucositis9 (6.1)9.74
Hypothyroidisma16 (10.8)10.717.6
Pneumonitis3 (2.6)10.914.9Yes4
  • aResolution of endocrine irAEs defined as symptom resolution.