Table 1.

Study characteristics of the eligible studies

StudyYearCountryNo. of centersType of studyRecruitment periodMedian age, range (y)No. of gender (male/female)Median follow-up, range (mo)
Logothetis (30)1996USA1Prospective1986–1994RC: 64 (mean). 35–7972/2831.7, NA
MVAC: 67 (mean), 32–79
ICT (31)1999Multination106Prospective1989–1995NA863/113NA
Sherif (32)2002MultinationNAProspective1991–1997RC: 67, 41–84249/60NA
CM: 66, 31–90
Grossman (14)2003USA126Prospective1987–1998RC: 63, 39–84251/568.7 years, 3.1–13 years
MVAC: 63, 36–79
Dash (18)2008USA1Retrospective2000–2006GC: 64, 56–7075/21NA
MVAC: 63, 58–67
Kaneko (19)2011Japan1Retrospective2007–2011GC: 69 (mean), 53–7824/718, 1–80
MVAC: 62 (mean), 53–74
Pal (21)2012USA1Retrospective1995–2012GC: 68.6, 64.4–71.4 (IQR)39/728.7, NA
MVAC: 60.1, 52.7–68.1 (IQR)
Scosyrev (20)2012USA1Retrospective1999–2009RC: 70, NA126/3432, NA
GC: 65, NA
Yeshchina (22)2012USA1Retrospective1988–2010GC: 66.0, NA77/37GC: 25, 1–120
MVAC: 62.9, NAMVAC: 30, 1–216
Fairey (26)2013USA1Retrospective1985–2011GC: 67, 43–8590/26NA
MVAC: 63: 34–82
Kitagawa (24)2013Japan1Retrospective1997–2010RC: 71.1 (mean), NA45/741.2 (mean), 4–170
MVAC: 64.3 (mean), NA
Lee (25)2013USA1Retrospective2003–2011NA136/42NA
Matsubara (23)2013Japan1Retrospective2005–2010RC: 64, 50–7631/1128.6, 3.4–64.9
GC: 67, 47–79
El-Gehani (27)2014Canada1Retrospective2007–2011RC: 72, 50–89120/40RC: 22.1, 1.7–74.6
GC: 65, 48–89GC: 34, 6.4–84.6
Kitamura (33)2014Japan28Prospective2003–2009RC: 63, 35–74117/1355, NA
MVAC: 63, 40–75
Gandhi (29)2015USA1Retrospective2000–2013RC: 63.7, 34–88222/49NA
GC: 62.5, 39–82
Zargar (28)2015Multination19Retrospective2000–2013GC: 65, 57–71 (IQR)617/16811, 3–27 (IQR)
MVAC: 62, 57–69 (IQR)

Abbreviations: ICT, international collaboration of trialists; IQR, interquartile range; NA, not available.