Table 4.

Protein level changes as continuous covariate and estimated HR for progression and death

PFSOS
Protein changeHR (95% CI)aHR (95% CI)b
sVEFGR20.79 (0.04–17.62)0.61 (0.03–14.33)
ANG20.40 (0.03–4.71)0.33 (0.02–4.75)
sTIE20.70 (0.37–1.31)0.56 (0.28–1.13)
IL60.40 (0.03–4.71)0.33 (0.02–4.75)
IL80.70 (0.37–1.31)0.56 (0.28–1.13)
CA90.44 (0.23–0.86)0.57 (0.30–1.07)

NOTE: HR corresponds to one unit increase in the log-transformed covariate; significant hazard ratio is shown in bold.

  • aHR adjusted for ECOG PS and first-line treatment.

  • bHR adjusted for hormone receptor status.