Table 2.

Multivariate Cox proportional hazards regression analysis of the derived RNA signatures and traditional characteristics with RFS

mRNA-only signatureIntegrated mRNA–lncRNA signature
Training setValidation setTraining setValidation set
VariableaHR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)P
Age (≤50 y as reference)1.06 (0.16–6.95)0.9491.29 (0.10–16.09)0.8451.01 (0.09–11.11)0.9951.18 (0.11–12.90)0.890
Menopause (no as reference)0.67 (0.12–3.73)0.6460.43 (0.03–5.77)0.5210.63 (0.07–5.38)0.6720.56 (0.05–6.18)0.635
Tumor grade (≤II as reference)1.61 (0.40–6.45)0.5010.71 (0.10–5.00)0.7291.79 (0.44–7.31)0.4160.91 (0.14–6.09)0.920
Tumor size (≤2 cm as reference)1.13 (0.34–3.70)0.8464.45 (0.48–41.47)0.1890.78 (0.20–2.99)0.7124.72 (0.51–43.68)0.171
Positive LNs (≤3 as reference)1.95 (0.53–7.24)0.3192.48 (0.53–11.53)0.2472.37 (0.61–9.16)0.2113.38 (0.70–16.31)0.130
Radiotherapy (no as reference)4.03 (0.93–17.39)0.0623.87 (0.64–23.49)0.1413.79 (0.83–17.31)0.0863.58 (0.63–20.33)0.151
Chemotherapy (non-taxane as reference)0.49 (0.15–1.57)0.2281.22 (0.25–5.95)0.8040.69 (0.17–2.74)0.5931.41 (0.27–7.26)0.683
Signature (low-risk as reference)4.46 (1.34–14.91)0.0156.31 (1.20–33.26)0.03010.00 (2.53–39.47)0.00114.04 (1.56–126.71)0.019

Abbreviation: LN, lymph node.

  • aAdjusted by Cox proportional hazards models including age, menopausal status, tumor grade, tumor size, positive lymph nodes, radiotherapy, chemotherapy, and integrated RNA signature.