Table 2.

Baseline protein levels as continuous covariate and estimated HR for progression and death

PFSaOSb
ProteinsHR (95% CI)HR (95% CI)
VEGF-A0.86 (0.62–1.18)0.94 (0.65–1.34)
sVEFGR20.57 (0.11–2.94)0.39 (0.07–2.33)
ANG22.54 (1.15–5.62)3.79 (1.69–8.50)
sTIE22.94 (0.85–10.13)4.23 (1.13–15.80)
IL61.49 (1.02–2.19)2.03 (1.39–2.97)
IL81.95 (1.31–2.91)2.83 (1.86–4.31)
CA91.75 (1.16–2.62)2.04 (1.35–3.11)
CA15-31.44 (1.10–1.89)1.33 (1.00–1.77)

NOTE: HR corresponds to one unit increase in the log-transformed covariate; significant HRs are shown in bold.

  • aHazard ratio adjusted for ECOG PS and first-line treatment.

  • bHazard ratio adjusted for hormone receptor status.