Table 1.

Binding of AGS16F and unconjugated AGS16-7.8 to human and cynomolgus monkey basophils

Sample and categoryAGS16FAGS16-7.8 AbControl Ab
Human basophils (n = 3)
 MFIR, mean (SE)
  Without hIgE stimulation94 ± 1.246 ± 4.38 ± 0.8
  With hIgE stimulation196 ± 19.7130 ± 4.69 ± 0.6
 % IgE+/ENPP3+
  Without hIgE stimulation0.75 ± 0.10.66 ± 0.10.07 ± 0.02
  With hIgE stimulation0.81 ±0.040.84 ± 0.10.09 ± 0.02
Monkey basophils (n = 3)
 MFIR, mean (SE)
  Without hIgE stimulation15 ± 0.8812 ± 0.679 ± 0.58
  With hIgE stimulation19 ± 3.2817 ± 0.09 ± 0.33
 % IgE+/ENPP3+
  Without hIgE stimulation0.26 ± 0.040.22 ± 0.020.10 ± 0.02
  With hIgE stimulation0.22 ±0.030.26 ± 0.020.09 ± 0.02

Abbreviation: MIFR, mean fluorescence intensity ratios.