Table 1.

Expression of surface antigens on CD34+/CD38 and CD34+/CD38+ cells in patients with CML and in normal/reactive BM

CP CMLAP CMLBP CMLNormal/reactive BM
CDAntigenCD34+/CD38CD34+/CD38+CD34+/CD38CD34+/CD38+CD34+/CD38CD34+/CD38+CD34+/CD38CD34+/CD38+
CD25IL-2RA+++/−++++++++/−
CD26DPPIV+++/−+++/−++/−
CD33Siglec-3+++++++++++++
CD44Pgp1++++++++++++++++
CD52Campath-1++/−n.t.n.t.++++
CD122IL-2RBn.t.n.t.
CD132IL-2RGn.t.n.t.n.t.n.t.
CD117KIT/SCFR++++++++n.t.n.t.++++
n.c.IL-1RAP++n.t.n.t.+++++/−

Abbreviations: IL-1RAP, IL1 receptor accessory protein; IL-2RB, IL-2 receptor beta; IL-2RG, IL-2 receptor gamma; n.c., not yet clustered; n.t., not tested; SCFR, stem cell factor receptor; ++, strongly expressed in a majority of cases; +, clear expression in majority of cases; +/−, expression in minority of cases or weak expression in majority of cases; −, no expression in a vast majority of cases.