Table 1.

Baseline characteristics

Training setValidation setP
Number of patients297482
Patient demographics
 Median age (min–max)70 (33–93)68 (29–95)0.013
 Male (number, %)179 (60%)266 (55%)0.16
Localization
 Colon185 (62%)258 (54%)
 Rectum112 (38%)224 (46%)0.017
Stage
 Stage I47 (16%)75 (16%)
 Stage II87 (29%)168 (35%)
 Stage III74 (25%)158 (33%)
 Stage IV72 (24%)51 (11%)<0.0001
 Unstaged17 (6%)30 (6%)
Type IV collagen concentration
 All patients (median)88 ng/mLa87 ng/mL
Adjuvant antineoplastic therapy
 Stage II11 (13%)14 (8%)0.27
 Stage III37 (50%)47 (30%)0.003

NOTE: Baseline characteristics of the two cohorts regarding demography (age and gender), tumor features (stage and localization), median concentration of the marker, and whether or not patients in stages II and III received adjuvant antineoplastic therapy of any sort.

  • aConcentration adjusted according to batch variation (Supplementary Data, Appendix S3).