Histologic grade (N = 324^{a}) | Genomic grade (N = 366^{a}) | |||
---|---|---|---|---|

HR (95% CI) | P | HR (95% CI) | P | |

Age^{b} | 1.67 (0.76–3.70) | 0.200 | 1.43 (0.69–2.99) | 0.340 |

Size^{c} | 2.30 (1.39–3.81) | 0.001 | 2.09 (1.33–3.30) | 0.002 |

Nodal Status^{d} | 1.30 (0.81–2.07) | 0.270 | 1.44 (0.94–2.22) | 0.090 |

Histologic grade^{e} | ||||

G1 | ref (—) | — | ref (—) | — |

G2 | 4.11 (1.63–10.34) | 0.003 | — | — |

G3 | 3.38 (1.26–9.08) | 0.016 | — | — |

Genomic grade^{f} | — | 1.62 (1.29–2.04) | <0.001 | |

MV score (continuous) | 0.70 (0.50–0.97) | 0.030 | 0.89 (0.65–1.21) | 0.450 |

NOTE: Patient numbers in each group (total

*N*= 380) Distant metastasis-free survival, HR per 25 increments in MV score.Abbreviation: ref, reference category.

↵

^{a}Reduced number of patients, missing cases shown below.↵

^{b}Age ≤ 50 years (*N*= 51) vs. Age > 50 years (*N*= 329).↵

^{c}Size ≤ 20 mm (*N*= 177) vs. size > 20 mm (*N*= 201), missing (*N*= 2).↵

^{d}Nodal status, negative (*N*= 177) vs. positive (*N*= 191), missing (*N*= 12).↵

^{e}Histologic grade, G1 (*N*= 71) vs. G_{2}(*N*= 179) vs. G3 (*N*= 86), missing (*N*= 44).↵

^{f}Genomic grade, GG1 (*N*= 224) vs. GG3 (*N*= 156).