Table 3.

Multivariate analysis of SMARCA4 expression and treatment arm (observation vs. cisplatin/vinorelbine) in the JBR.10 Trial

Multivariate analysis (DSS)Multivariate analysis (5 YR DSS)Multivariate analysis (OS)Multivariate analysis (5 YR OS)
ProbeVariableComparisonHR (95% CI)PHR (95% CI)PInteraction P valueaHR (95% CI)PHR (95% CI)PInteraction P valuea
ACT vs. OBS0.3 (0.1–0.8)0.020.1 (0.0–0.5)0.0020.010.4 (0.2–0.9)0.020.1 (0.0–0.5)<0.0010.007
Low SMARCA4Stage: II vs. I5.3 (2.0–14.1)<0.0015.9 (1.8–18.7)0.0033.1 (1.4–6.9)0.0055.0 (1.8–14.4)0.003
Age: ≥65 vs. <652.6 (1.0–7.0)0.054.2 (1.3–13.8)0.022.3 (1.0–5.2)0.054.2 (1.5–12.1)0.008
Histology: SQCC vs. ADC0.6 (0.2–1.6)0.290.7 (0.2–2.3)0.600.7 (0.3–1.6)0.430.9 (0.3–2.5)0.83
Histology: LCUC vs. ADC4.3 (1.1–17.5)0.048.1 (1.8–37.0)0.0072.6 (0.7–9.5)0.166.8 (1.6–29.3)0.01
213719_s_at
ACT vs. OBS1.0 (0.4–2.1)0.911.0 (0.5–2.3)0.921.0 (0.5–2.1)0.991 (0.5–2.2)0.96
High SMARCA4Stage: II vs. I1.5 (0.7–3.2)0.331.4 (0.6–3.0)0.421.4 (0.7–2.8)0.401.4 (0.6–2.9)0.41
Age: ≥65 vs. <652.5 (1.1–5.4)0.032.5 (1.1–5.7)0.022.7 (1.3–5.7)0.012.6 (1.2–5.5)0.02
Histology: SQCC vs. ADC0.3 (0.1–0.6)0.0030.3 (0.1–0.7)0.0050.3 (0.1–0.7)0.0040.3 (0.1–0.7)0.005
Histology: LCUC vs. ADC1.1 (0.3–4.0)0.831.2 (0.3–4.2)0.781.1 (0.3–3.7)0.931.1 (0.3–4)0.84
ACT vs. OBS0.4 (0.2–0.9)0.030.3 (0.1–0.9)0.030.220.5 (0.2–1.2)0.130.4 (0.2–1.0)0.040.37
Low SMARCA4Stage: II vs. I3.6 (1.4–8.9)0.0072.8 (1.0–7.6)0.052.7 (1.2–6.0)0.023.0 (1. 1–8.1)0.03
Age: ≥65 vs. <652.3 (0.9–5.5)0.072.4 (0.9–6.4)0.091.8 (0.8–4.0)0.172.1 (0.8–5.4)0.14
Histology: SQCC vs. ADC0.4 (0.1–1.0)0.050.5 (0.2–1.4)0.180.3 (0.1–0.7)0.010.4 (0.2–1.3)0.13
Histology: LCUC vs. ADC4.9 (0.9–26.0)0.066.6 (1.2–37.0)0.032.8 (0.6–13.5)0.215.9 (1.1–32.4)0.04
208794_s_at
ACT vs. OBS0.9 (0.4–1.9)0.700.7 (0.3–1.7)0.460.7 (0.4–1.5)0.430.7 (0.3–1.4)0.29
High SMARCA4Stage: II vs. I2.0 (0.9–4.4)0.072.1 (0.9–4.7)0.081.6 (0.8–3.2)0.171.9 (0.9–4.0)0.09
Age: ≥65 vs. <652.0 (0.9–4.6)0.092.3 (1.0–5.4)0.052.8 (1.3–5.8)0.0072.8 (1.3–6.1)0.01
Histology: SQCC vs. ADC0.5 (0.2–1.3)0.150.6 (0.2–1.4)0.230.7 (0.3–1.6)0.450.7 (0.3–1.6)0.39
Histology: LCUC vs. ADC1.7 (0.6–5.3)0.342.0 (0.7–6.3)0.221.7 (0.6–5.1)0.361.9 (0.6–6.0)0.25

Abbreviations: ADC, adenocarcinoma; SQCC, squamous cell carcinoma; LCUC, large cell carcinoma.

  • aInteraction P values displayed are for 5-year DSS or OS.