Table 2.

IC50 of topotecan in neuroblastoma and rhabdomyosarcoma cell lines

IC50 (nmol/L)
Normoxia1% O2, 2 hours1% O2, O/NPa
Neuroblastoma cell lines
CHLA-1517.6 ± 3.915.6 ± 0.913.7 ± 1.4NSb
CHLA-2012.9 ± 1.212.4 ± 1.014.1 ± 0.6NS
CHLA-904,170 ± 1,0304,550 ± 1,5905,260 ± 724NS
SK-N-BE(2)96.2 ± 11.8110 ± 13.895.0 ± 14.3NS
SH-SY5Y19.2 ± 7.012.4 ± 1.114.1 ± 0.6NS
Rhabdomyosarcoma cell lines
RH4132 ± 10.0110 ± 21.8119 ± 3.7NS
RH302,251 ± 6851,963 ± 4161,621 ± 174NS
RD387 ± 55.8250 ± 87.5317 ± 22.9NS
  • aP value from one-way ANOVA.

  • bNS, not significant, P > 0.05