Table 2.

Clinicopathologic features of NSCLC patients according to MET protein expression by immunohistochemical analysis

MET Protein expression by IHC
TotalPositiveNegative
Characteristicsn = 687n = 230n = 457P
Histology
 AD392195197<0.001a
 SCC18010170<0.001a
 LCC457380.008a
 ADSQ219120.356a
 LELC27027<0.001a
 PSC229130.49a
Gender
 Female223951280.001
 Male464135329
Stage
 IA–IIIA5831873960.056
 IIIB–IV913952
Smoking history
 Never22399124<0.001
 Ever395110285
Age
 Mean ± SD68763.4 ± 12.565.0 ± 10.40.088
Tumor size
 Mean ± SD6713.5 ± 1.74.4 ± 2.3<0.001
METΔ14 mutation
 Positive18180<0.001
 Negative669212457
Cappuzzo
 Positive20164<0.001
 Negative667214453
PathVysion
 Positive880<0.001
 Negative679222457
High-level amplification
 Positive24231<0.001
 Negative663207456
MET FISH+
 Positive29254<0.001
 Negative658205453
 H-Amp880
 Polysomy990
 L-Amp/H-GCN761
 L-Amp/L-GCA523
MET DNA alterations
 Positive41374<0.001
 Negative646193453
  • aVersus all other histologic types.