Table 1.

HR deficiency status and association with response to platinum-containing therapy

PrECOG 0105 (N = 70)
ResponderDeficient number (% response)Nondeficient number (% response)OR (95% CI) Reference = nondeficientLogistic P
RCB 0/I = No1614
RCB 0/I = Yes34 (68%)6 (30%)4.96 (1.61–15.3)0.0036
pCR = No2918
pCR = Yes21 (42%)2 (10%)6.52 (1.36–31.2)0.0058
Cisplatin Trials Cohort (N = 50)
ResponderDeficient number (% response)Nondeficient number (% response)OR (95% CI) Reference = nondeficientLogistic P
RCB 0/I = No1419
RCB 0/I = Yes15 (51.7%)2 (9.5%)10.18 (2.00–51.89)0.0011
pCR = No2121
pCR = Yes8 (27.5%)0 (0%)17.00 (1.91–2,249)a0.0066a
  • aBased on Firth's penalized profile likelihood.