Table 2.

Patient and tumor characteristics for 281 patients classified with a more or less hypoxic tumor by the 6-gene classifier based on Illumina BeadArray data

All patients (n = 281)More hypoxic (n = 100)Less hypoxic (n = 181)
Characteristicn (%)n (%)n (%)Pa
Age (years)1.00
 Median54.554.454.7
 Range21.8–84.221.8–83.924.3–84.2
 <54.5 years140 (50)50 (50)90 (50)
 ≥54.5 years141 (50)50 (50)91 (50)
FIGO stage0.037
 IB–IIB202 (72)64 (64)138 (76)
 IIIA–IVA79 (28)36 (36)43 (24)
Tumor volume (cm3)b0.0019
 Median36.853.828.3
 Range1.9–321.05.3–321.01.9–302.0
 <36.8 cm3132 (50)34 (37)98 (57)
 ≥36.8 cm3132 (50)59 (63)73 (43)
Pelvic lymph node statusc0.032
 Positive121 (43)52 (52)69 (38)
 Negative160 (57)48 (48)112 (62)
  • aFisher exact test for comparisons between the more and less hypoxic group.

  • bDetermined from pretreatment MR images. Calculated based on 3 orthogonal diameters (a, b, c) as (π/6)abc. Tumor volume was undetermined for 17 tumors due to lack of MRI: 7 in the more and 10 in the less hypoxic group.

  • cDetermined from pretreatment MR or, for 17 patients, CT images.