Table 1.

Patient and cyst characteristics (patients whose cyst fluid samples had not undergone prior thawing)

CharacteristicsTotal (n = 119)IPMN (n = 74)MCN (n = 10)SCN (n = 25)PanNET (n = 4)Pseudocyst (n = 5)Simple cyst (n = 1)
Male/female (n)55/6442/320/106/193/14/10/1
Age (median, range), y65 (29–87)69 (42–87)52 (30–61)63 (29–77)57 (43–75)73 (54–82)64
Symptoms (n)
 Abdominal pain201125020
 Pancreatitis141211000
 Jaundice1100000
Cyst location (n)
 Head and uncinate/body and tail54/6540/340/1011/141/32/30/1
Cyst size, median (range), cm2.5 (0.5–11.5)2.0 (0.5–9.0)2.6 (1.6–7.0)2.5 (1.5–10.0)5.5 (2.5–7.6)3.8 (2.5–11.5)1.5
Mural nodule (n)a
 Absent/present76/4345/2910/016/90/44/11/0
Communication with MPD (n)a
 Absent/present73/4633/4110/020/54/05/01/0
Dilatation of MPD ≥10 mm (n)a
 Absent/present105/1460/1410/025/04/05/01/0
Dilatation of MPD ≥5 mm (n)a
 Absent/present84/3542/3210/024/13/14/11/0
CT/MRI findings (n)
 Worrisome features7242516450
 High-risk stigmata211902000
 No concerning features261357001
Cyst fluid color (n)
 Bloody/sero-bloody/brown/straw/clear26/51/13/5/2417/35/4/3/150/2/2/0/67/12/4/0/22/1/1/0/00/1/2/2/00/0/0/0/1
Cyst fluid appearance (n)
 Serous/mucinous63/5623/519/123/23/14/11/0
Original cyst volume (median, range), μL139 (10–1,000)92.5 (10–800)250 (50–600)250 (120–1,000)125 (80–200)50 (50–200)400
EUS cytology (n = 45), n
 Nondiagnostic6213000
 Benign/atypia/cancer20/9/1012/8/103/0/04/1/01/0/00/0/00/0/0
Cyst fluid CEA (n = 23), n
 <192 ng/mL/≥192 ng/mL16/77/52/26/01/00/00/0
Operative procedure (n)
 PD/DP/TP/MP56/58/3/242/28/2/20/10/0/012/13/0/00/3/1/02/3/0/00/1/0/0
Morphologic duct type (n)a
 Main duct/mixed/branch duct14/18/42
Grade of dysplasia (n)bNET G1 n = 3
 LGD/IGD/HGD/Cancer7/36/20/117/3/0/0NET G2 n = 1
  • Abbreviations: CEA, carcinoembryonic antigen; DP, distal pancreatectomy; HGD, high-grade dysplasia; IGD, intermediate grade dysplasia; IPMN, intraductal papillary mucinous neoplasm; LGD, low grade dysplasia; MCN, mucinous cystic neoplasm; MP, middle pancreatectomy; MPD, main pancreatic duct; PanNET, pancreatic neuroendocrine tumor; PD, pancreaticoduodenectomy; SCN, serous cystic neoplasm; TP, total pancreatectomy.

  • aDetermined by CT/MRI.

  • bHistologic grade of PanNET was diagnosed on the basis of WHO 2010 criteria.