Table 3.

CNS efficacy endpoints' pooled analyses (NP28761 and NP28673)

Patients with measurable CNS disease at baseline (n = 51)
Efficacy parameterRECIST v1.1 criteriaRANO criteria
CORR (95% CI)61% (46–74)51% (35–67)
Median CDOR, months (95% CI)9.1 (5.8–NE)9.1 (7.4–NE)
  • Abbreviations: CI, confidence interval; NE, not estimable.