Table 5.

Most common grades 3–4 adverse reactions and laboratory abnormalities (incidence ≥2%) in NP28761 and NP28673

Alectinib 600 mg b.i.d. (n = 253)
Adverse reactionGrades 3–4
 Dyspneaa3.6%
Laboratory abnormality
 Increased alanine aminotransferase4.8%
 Increased creatine phosphokinaseb4.6%
 Lymphopeniac4.6%
 Hypokalemia4.0%
 Increased aspartate aminotransferase3.6%
 Hypophosphatemia2.8%
 Hyperbilirubinemia2.4%
 Hyperglycemiad2.0%
 Hyponatremia2.0%
 Anemia2.0%
  • Abbreviation: b.i.d., twice daily.

  • aIncludes one grade 5 event.

  • bn = 218 for creatine phosphokinase (with baseline values missing for 91 of these patients).

  • cn = 217 for lymphocytes (with baseline values missing for 5 of these patients).

  • dn = 152 for fasting blood glucose (with baseline values missing for 5 of these patients).