Table 4.

Common adverse reactions (incidence ≥20%) and laboratory abnormalities (incidence ≥30%) in NP28761 and NP28673

Alectinib 600 mg b.i.d. (n = 253)
Adverse reactionAll grades
 Fatigue41%
 Constipation34%
 Edema30%
 Myalgia29%
Laboratory abnormality
 Anemia56%
 Increased aspartate aminotransferase51%
 Increased alkaline phosphatase47%
 Increased creatine phosphokinasea43%
 Hyperbilirubinemia39%
 Hyperglycemiab36%
 Increased alanine aminotransferase34%
 Hypocalcemia32%
  • Abbreviation: b.i.d., twice daily.

  • an = 218 for creatine phosphokinase (with baseline values missing for 91 of these patients).

  • bn = 152 for fasting blood glucose (with baseline values missing for 5 of these patients).