Table 1.

List of drugs tested during systemic BRAF inhibition with respective molecular targets

CompoundPLX4720Byl719ImatinibCrizotinib17-DMAGErlotinibLapatinib
Molecular targetBRAF V600EPI3KV-Abl, c-Kit, PDGFRC-Met, ALKHSP90EGFRHER2/EGFR
CompoundPalbociclibPD173074VorinostatYH239-EESCH772984Doxorubicin
Molecular targetCDK 4/6FGFR1HDACp53-MDM2ERK1/2DNA-damaging agent
  • Abbreviation: ALK, anaplastic lymphoma kinase.