Table 1.

Patient and tumor characteristics

Patient characteristics
Germline BRCA1 mutationHistopathology and IHCMolecular analyses
IDAgeExonMutation (c.)Tumor typeGradeER%PR%HER2p53%KI67%BRCA1-likeBRCA1 scoreBRCA2-likeBRCA2 scoreMethylationLOH analysis
15311c.2210delCILC11000Neg0NDSP-like0SP-like0.28No methLoss wt allele
25511c.2210delCIDC31000Neg0NDSP-like0B2-like0.94No methLoss wt allele
34013c.4186-1632_4357+2031del3835IDC2100100Neg100NDSP-like0.019SP-like0.002No methLoss wt allele
43920c.5266dupCMixed39070Neg<10NDSP-like0.002B2-like0.69No methLoss wt allele
53822c.5333-36_5406+400del510IDCND10030Neg20NDSp-like0.16B2-like1No methND
67214c.4416_4417delTTinsGIDC1100NDNDNDNDSP-like0SP-like0No methROH
74111c.3820dupGILCND7510Neg955Sp-like0.45Sp-like0.16NDLoss wt allele
86611c.2989_2990dupAAIDCND10060Neg115B1-like0.76B2-like0.59No methLoss wt allele
94722c.5333-36_5406+400del510IDCND90<5Neg9080Sp-like0.35Sp-like0.001No methLoss wt allele
104222c.5333-36_5406+400del510IDCND50Neg8090Sp-like0.41Sp-like0No methLoss wt allele
116220c.5266dupCIDC3200Neg125B1-like1B2-like1No methLoss mut allele
125817c.4987-?_5074+?delIDC31005PosND30Sp-like0.01B2-like0.997NDND
13685c.181T>GIDC31001NegND40Sp-like0.01B2-like0.998NDLoss wt allele
143922c.5333-36_5406+400del510IDCND9080Neg010SP-like0.003B2-like0.67No methND
15435c.181T>GIDC21000NegNDNDSP-like0B2-like1NDND
164322c.5333-36_5406+400del510IDC2100100Neg100NDSP-like0.04B2-like0.68NDLoss wt allele
  • Abbreviations: IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; meth, methylation; mut, mutant; ND, not determined; ROH, retention of heterozygosity; wt, wild type.