Top enriched gene sets in MSigDB all canonical pathways and GO biological process in ASO-6w2 versus Scrb-treated LTL-313BR tumors
| Functions | ASO-6w2 vs. Scrb - Top enriched gene sets | Up/down | FDR |
|---|---|---|---|
| GPCR signaling | Reactome signaling by GPCR | ↓ | 8.06E−19 |
| Reactome GPCR ligand binding | ↓ | 3.63E−14 | |
| Reactome G alpha I signalling events | ↓ | 4.96E−11 | |
| Matrisome (extracellular matrix) | Naba matrisome | ↑↓ | 1.33E−15 |
| Naba matrisome associated | ↑↓ | 3.08E−13 | |
| Receptor activity | ↓ | 7.00E−11 | |
| Transmembrane transport | Establishment of localization | ↑ | 3.08E−16 |
| Transport | ↑ | 1.35E−15 | |
| Reactome transmembrane transport of small molecules | ↑ | 2.07E−12 | |
| Reactome SLC-mediated transmembrane transport | ↑ | 1.34E−08 | |
| Response to external stimulus | Response to external stimulus | ↑ | 4.10E−15 |
| Response to wounding | ↑ | 3.05E−13 | |
| Response to stress | ↑ | 1.23E−10 |
NOTE: Analysis was based on gene expression profiling in ASO-6w2- and Scrb-treated LTL-313BR xenografts (n = 4 per group; fold change > 1.5).