Treatment-related abnormal hematology laboratory values by dosea
| Urelumab dose | |||
|---|---|---|---|
| 0.1 mg/kg (n = 61)b | 0.3 mg/kg (n = 56)b | ≥1 mg/kg (n = 229)b | |
| Absolute neutropenia, n (%) | |||
| Total grade 1–4 | 14 (23) | 19 (34) | 64 (28) |
| Grade 1 | 6 (10) | 9 (16) | 28 (12) |
| Grade 2 | 3 (5) | 3 (5) | 13 (6) |
| Grade 3 | 2 (3) | 3 (5) | 7 (3) |
| Grade 4 | 3 (5) | 4 (7) | 16 (7) |
| Thrombocytopenia, n (%) | |||
| Total grade 1–4 | 12 (20) | 25 (45) | 63 (28) |
| Grade 1 | 7 (11) | 24 (43) | 46 (20) |
| Grade 2 | 3 (5) | 0 | 7 (3) |
| Grade 3 | 1 (2) | 0 | 7 (3) |
| Grade 4 | 0 | 1 (2) | 3 (1) |
| Leukopenia, n (%) | |||
| Total grade 1–4 | 10 (33) | 19 (34) | 84 (37) |
| Grade 1 | 13 (21) | 8 (14) | 50 (22) |
| Grade 2 | 2 (3) | 5 (9) | 15 (7) |
| Grade 3 | 4 (7) | 4 (7) | 14 (6) |
| Grade 4 | 1 (2) | 2 (4) | 5 (2) |