Table 1.

Initial patient characteristics (N = 40)

Patients (N = 40)
Median age (range)65 (35–82)
Female14 (35%)
Male26 (65%)
Del (17p)a21 (52%)
Del (11q)12 (30%)
Del (13q)5 (12.5%)
FISH negative2 (5%)
Mutation status IGVH (immunoglobulin heavy chain variable region)Unmutated (33), not done (6), mutated (1)
Median (range)
Prior treatments2.0 (0–8)
Cycles completed42 (2–49)
Median follow-up time of alive patients (months)47 (36–51)
Hemoglobin (g/dL)11.7 (6.7–15.6)
Platelets (103/μL)91.5 (36–242)
White blood cell count (103/μL)22.4 (2.2–297.8)
Absolute lymphocytes (103/μL)19.9 (0.4–277)
  • aOverall, among the 40 patients, 21 were del17p by FISH, of which only 3 were del17p alone, and the distribution of other FISH abnormalities in the remaining 18 patients was as follows: 1 with del11q, 1 with 11q and trisomy 12, 2 with trisomy 12, 6 with del11q and del13q, and 8 with del13q. Similarly, there were 12 patients with del11q (without del17p), of which only 4 were del11q alone and 8 were del11q with del13q.