Table 4.

CD4 and CD8 immune outcomes in the peripheral blood and in the SLNs by pathologic response in 42 DCIS patients

Pathologic response
Non-pCR, n = 30pCR, n = 12
n (%)Exact 95% CIn (%)Exact 95% CIP
Overall CD4 PB
 Immune respondersa25 (86.2)68.3–96.18 (66.7)34.9–90.10.20
Overall CD8 PB
 Immune respondersb11 (73.3)44.9–92.21 (33.3)0.8–90.50.51
Overall CD4 SLN
 Immune respondersc18 (72.0)50.6–87.97 (100)65.2d0.17
  • Abbreviations: CI, confidence interval; PB, peripheral blood.

  • aOne patient (non-pCR) not evaluable for overall CD4 peripheral immune response.

  • b18 total HLA-A2+ patients evaluated for CD8 peripheral immune response (15 non-pCR, 3 pCR).

  • c32 total patients evaluated for SLN CD4 immune response (25 non-pCR, 7 pCR).

  • dLower bound of one-sided exact 95% CI.