Table 2.

Adjusted RRs (95% CIs) of toxicity for body composition measures

ParameterAny grade 3/4 toxicityGrade 3/4 hematologic toxicityGrade 3/4 GI toxicityGrade 3/4 neuropathyHospitalizationDose delay/reduction
LBM (5 kg decrease)1.48 (1.15–1.89)a1.27 (0.88–1.84)2.87 (1.60–5.15)b1.52 (0.92–2.51)1.07 (0.74–1.55)1.14 (0.86–1.53)
SMI (5 cm2/m2 decrease)1.29 (1.10–1.53)a1.11 (0.86–1.43)1.83 (1.20–2.80)a1.20 (0.78–1.83)0.91 (0.71–1.16)1.02 (0.83–1.26)
SMD (5 HU decrease)1.13 (0.97–1.32)1.03 (0.83–1.27)1.75 (1.30–2.36)b1.09 (0.67–1.75)1.34 (1.07–1.68)c1.14 (0.97–1.33)
SMG (100 AU decrease)1.09 (1.02–1.16)c1.02 (0.94–1.11)1.41 (1.19–1.67)b1.08 (0.90–1.28)1.08 (0.98–1.20)1.05 (0.99–1.12)
SMG (<1,475 AU vs. ≥1,475)2.18 (1.34–3.54)a2.12 (1.11–4.04)c6.49 (1.42–29.63)c1.63 (0.43–6.27)1.91 (1.00–3.66)c1.63 (0.98–2.73)
  • NOTE: Adjusted for age and BSA at diagnosis.

  • Abbreviations: BSA, body surface area; CI, confidence interval; LBM, lean body mass; RR, relative risk; SMD, skeletal muscle density; SMG, skeletal muscle gauge; SMI, skeletal muscle index.

  • aP < 0.01.

  • bP < 0.001.

  • cP < 0.05.