Table 5.

Serum levels of biomarkers

Baseline (n = 29)C2D1 (n = 26)C3D1 (n = 23)Last visit (n = 29)
BMP9 (pg/mL)
 Mean (SD)19.4 (12.40)6.8 (2.46)7.7 (2.34)7.9 (2.58)
 Median156.87.57.5
 Min–Max4.6–51.02.4–13.03.5–14.02.1–16.0
P<0.0001<0.0001<0.0001
sEnd (ng/mL)
 Mean (SD)3.5 (0.82)3.3 (0.71)3.2 (0.70)3.2 (0.65)
 Median3.53.43.33.2
 Min–Max2.2–5.52.2–4.71.9–4.81.5–4.4
P0.19620.11490.1058
PlGF (pg/mL)
 Mean (SD)42.7 (22.92)93.6 (65.68)80.2 (43.76)68.7 (53.36)
 Median33.073.079.051.0
 Min–Max29.0–137.029.0–291.029.0–213.029.0–276.0
P<0.0001<0.00010.0032
VEGF (pg/mL)
 Mean (SD)377 (159.1)494 (261.9)405 (164.2)490 (224.4)
 Median360.0417.5378.0439.0
 Min–Max89.0–704.0147.0–1,120.0171.0–772.0189.0–933.0
P0.00070.00270.0011
VEGFR2 (ng/mL)
 Mean (SD)4.8 (1.16)3.7 (0.69)3.4 (0.74)3.9 (1.08)
 Median4.43.93.44.1
 Min–Max3.1–8.12.5–5.21.9–4.42.1–6.1
P<0.0001<0.0001<0.0001
VEGFR3 (ng/mL)
 Mean (SD)47.0 (23.68)12.2 (7.88)9.0 (6.24)16.0 (10.40)
 Median43.09.57.916.0
 Min–Max20.0–132.02.2–35.01.4–26.01.9–47.0
P<0.0001<0.0001<0.0001
  • NOTE: P values derived from paired t tests; each time point compared with baseline.

  • Abbreviations: Max, maximum; Min, minimum; SD, standard deviation.