Table 3.

Key human pharmacokinetic parameters for biological drugs approved for oncology indications

Generic nameBrand nameDoseDose unitRouteInfusionCmax (μmol/L)AUC (μg•hr/mL)TmaxT1/2 (days)
Ado-trastuzumab emtansineKadcyla3.6mg/kgIV90 min0.57219.8End of infusion4.2
Free DM1(Kadcyla)0.006
AldesleukinProleukin1.1mgSC0.001590.01572.5 h0.071
AlemtuzumabCampath30mgIV2 h0.073566
Asparaginase (Escherichia coli)Elspar5,000U/m2IV30 min0.516843070.771
Asparaginase (Erwinia chrysanthemi)Erwinaze30,000IU/m2IV3 h20 IU/mL0.267
AtezolizumabTecentriq1,200mgIV60 min2.7900027
BevacizumabAvastin10mg/kgIV30 min1.9060421
BlinatumomabBlincyto28μgIV24 h0.0000110.0875
Brentuximab vedotinAdcetris1.8mg/kgIV30 min0.209153.190.089 d4.43
Free MMAE(Adcetris)0.006960.00152.09 d3.6
CetuximabErbitux400mg/m2IV2 h1.4062219,0003 h3.13
DaratumumabDarzalex16mg/kgIV6.5 h6.1824318
Denileukin diftitoxOntak19μg/kgIV60 min1,309 U/mL33,482 U•min/mL0.056
DenosumabProlia60mgSC0.0459213.210 d25.4
DenosumabXgeva180mgSC0.211565510 d29.1
DinutuximabUnituxin17.5mg/m2IV10–20 h0.0766710
ElotuzumabEmpliciti10mg/kgIV15–60 min2.2781940,7014.1 h0.197
FilgrastimNeupogen5μg/kgIV15–30 min0.010040.6380.463
Gemtuzumab ozogamicinMylotarg9mg/m2IV2 h0.018691233.02
Free calichaemicin(Mylotarg)0.003650.224.21
Interferon alfa-2bIntron A20 × 106IUIV20 min0.000310.00950
IpilimumabYervoy3mg/kgIV90 min0.54730
NecitumumabPortrazza800mgIV60 min3.5151967,8215.21
NivolumabOpdivo3mg/kgIV60 min0.4103415,8133.1 h17
ObinutuzumabGazyva1,000mgIVSee label3.7577036628.4
OfatumumabArzerra2,000mgIVSee label10.14374674,46315.8
OlaratumabLartruvo15mg/kgIV60 min3.0970042,4002.53 h7.21
OprelvekinNeumega50μg/kgSC0.001000.2422.7 h0.3375
PaliferminKepivance90μg/kgIVBolus0.122280.2320.196
PanitumumabVectibix6mg/kgIV60 min1.4489854.47.5 d
PegaspargaseOncaspar2,500IU/m2IV1–2 hr0.357407
PegfilgrastimNeulasta100μg/kgSC0.0058729.348 h0.883
Peginterferon alfa-2bPEG-Intron6μg/kgSC0.000140.432.125
PembrolizumabKeytruda2mg/kgIV30 min0.4409058.70.17 d26
PertuzumabPerjeta420mgIV30–60 min1.013512,76219.1
RamucirumabCyramza8mg/kgIV60 min1.1632718,3007.54
RasburicaseElitek0.2mg/kgIV30 min0.1137545.20.879
RituximabRituxan375mg/m2IVSee label3.22397
RomiplostimNplate1μg/kgIVBolus0.000220.02670.1
SiltuximabSylvant11mg/kgIV60 min2.2896620.6
Thyrotropin alfaThyrogen0.9mgIM0.0012210 h1.04
TrastuzumabHerceptin6mg/kgIV90 min1.4842212
Ziv-afliberceptZaltrap4mg/kgIV1 h1.0051612.25.5
  • Abbreviations: BLOQ, below the limit of quantitation; d, days; hr, hour(s); IM, intramuscular; IV, intravenous; min, minutes; PO, per os; SC, subcutaneous; Tmax: time post-dose of maximum plasma concentration; T1/2: plasma half-life.