Table 1.

Unadjusted RRs (95% CIs) of toxicity for body composition measures

Any grade 3/4 toxicity (N = 50)Grade 3/4 hematologic toxicity (N = 35)Grade 3/4 GI toxicity (N = 7)Grade 3/4 neuropathy (N = 11)Hospitalization (N = 30)Dose delay/reduction (N = 48)
Sarcopenic and obesea1.86 (0.88–3.96)3.02 (1.38–6.63)b2.92 (0.46–18.61)2.65 (1.61–4.39)b
BMI (1 kg/m2 decrease)1.00 (0.97–1.04)1.00 (0.96–1.04)1.00 (0.88–1.13)0.94 (0.89–1.00)0.98 (0.93–1.02)1.00 (0.96–1.04)
BSA (1 m2 decrease)1.21 (0.41–3.55)1.50 (0.35–6.45)1.68 (0.02–161.2)0.21 (0.02–2.29)1.24 (0.29–5.33)1.33 (0.43–4.16)
LBM (5 kg decrease)1.36 (1.12–1.66)b1.25 (0.95–1.65)2.03 (0.90–4.59)1.25 (0.78–2.00)1.09 (0.81–1.48)1.14 (0.92–1.43)
SMI (5 cm2/m2 decrease)1.27 (1.09–1.49)b1.13 (0.92–1.40)1.69 (0.97–2.94)1.12 (0.75–1.67)1.29 (0.68–2.45)1.05 (0.87–1.26)
SMD (5 HU decrease)1.11 (0.98–1.25)1.03 (0.87–1.21)1.36 (0.91–2.03)1.29 (0.96–1.75)1.19 (1.00–1.43)c1.08 (0.95–1.23)
SMG (100 AU decrease)1.08 (1.02–1.15)b1.03 (0.95–1.11)1.28 (1.08–1.51)b1.15 (1.00–1.31)c1.07 (0.98–1.16)1.04 (0.99–1.10)
SMG (<1,475 AU vs. ≥1,475)2.15 (1.36–3.40)b2.00 (1.08–3.72)c3.90 (0.78–19.44)2.73 (0.84–8.92)1.82 (0.96–3.43)1.56 (0.98–2.47)
VAT area (1 unit decrease)1.00 (1.00–1.00)1.00 (1.00–1.01)1.00 (0.99–1.01)1.00 (0.99–1.00)1.00 (0.99–1.00)1.00 (1.00–1.00)
VAT density (1 unit decrease)1.00 (0.97–1.03)0.99 (0.95–1.02)0.99 (0.92–1.06)1.04 (0.93–1.16)1.01 (0.97–1.05)0.99 (0.97–1.02)
SAT area (1 unit decrease)1.00 (1.00–1.00)1.00 (1.00–1.00)1.00 (0.99–1.00)1.00 (1.00–1.00)1.00 (1.00–1.00)1.00 (1.00–1.00)
SAT density (1 unit decrease)1.01 (0.97–1.05)1.01 (0.96–1.06)0.98 (0.89–1.08)1.02 (0.92–1.13)1.01 (0.96–1.06)0.98 (0.95–1.02)

Abbreviations: BMI, body mass index; BSA, body surface area; CI, confidence interval; GI, gastrointestinal; LBM, lean body mass; RR, relative risk; SAT, subcutaneous adipose tissue; SMD, skeletal muscle density; SMG, skeletal muscle gauge; SMI, skeletal muscle index; VAT, visceral adipose tissue.